THE PROJECT

MagicCELLGene is a project funded by M-ERA.net and developed through an international collaboration of groups from CSIC, UNIZAR and NOVA.ID.

The goal of MagicCELLGene is to develop a novel, universal and highly efficient methodology for transfection triggered by magnetic hyperthermia, with potential clinical applications in cell-based gene therapy. Our innovative approach is to induce a controlled and localized heating of the cellular membrane (hotspots) using magnetic nanoparticles covalently immobilized onto cell membranes via bioorthogonal chemistry; the reversible changes of the cell membrane permeability/fluidity will be used to promote the artificial delivery of nucleic acids into cells. Efforts will be especially focused on hard-to-transfect cells (primary cells), thus clearly addressing an unmet need of the transfection market. Expected results going beyond the state-of-the-art in transfection are: i) the development of a universal transfection tool and ii) its application to systems where standard transfection methods have several bottlenecks using as a model immune system modulation.

THE PARTNERS

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NEWS

RADIO

CSIC and UNIZAR teams in Ágora (Aragón Radio) - 12/04/2018

PRESS

Press release on the website of ICMA - 26/03/2018

Contact

ERA-NET for materials research and innovation

Acciones de programación conjunta internacional 2017

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